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. 2020 Jan 1;10(2):553–566. doi: 10.7150/thno.37181

Figure 4.

Figure 4

Knockdown of miR-153-3p suppresses ISO-induced mitochondrial fission and hypertrophy in cardiomyocytes. (A) Cardiomyocytes were transfected with anta-153-3p or anta-NC and exposed to ISO. The level of miR-153-3p was determined by qRT-PCR. *p < 0.05. (B) Knockdown of miR-153-3p inhibits ISO-induced mitochondrial fragmentation. Cardiomyocytes were treated as described in (A). Quantification of the percentage of cardiomyocytes with fragmented mitochondria. (C-F) Cardiomyocytes were treated as described in (A). Quantitative measurement of cell surface area (C). Representative images of sarcomere organization in cardiomyocytes (D). Bar = 20 µm. The mRNA levels of ANP (E) and β-MHC (F) were detected by qRT-PCR. *p < 0.05.