Figure 2.

bmMSC therapy causes fistula closure confirmed on pelvic MRI. [A] Magnetic resonance images [MRI] of the perianal region of two patients treated with bmMSC therapy. Above: images at baseline and after 4 years from a patient treated in cohort 2. The fistula tract is completely closed, with only scar tissue being present 4 years after bmMSC therapy. Under: images at baseline and after 4 years from a patient treated in cohort 3. Fistula tracts that contained fluid before bmMSC therapy are closed 4 years later. Arrows: fluid inside the fistula tracts. Asterisks: scar tissue. [B] Maximum fistula diameter [mm] at baseline and 4 years after MSC therapy [n = 9]; **p <0.01.