Table 1.
Variable | CD [n = 35] | UC [n = 15] | p-value |
---|---|---|---|
Gender | 0.849 [overall chi 2 ] | ||
Male | 13 [37%] | 6 [40%] | 0.849 [Z test] |
Female | 22 [63%] | 9 [60%] | 0.849 [Z test] |
Age at operation [years] | 36.9 ± 2.27 | 37.8 ± 3.10 | 0.814 [t test] |
Age at diagnosis [years] | 29.7 ± 2.05 | 35.3 ± 3.99 | 0.228 [t test] |
Disease duration [months] | 91.1 ± 16.11 | 63.6 ± 22.19 | 0.779 [t test] |
Family history | 0.198 [overall chi 2 ] | ||
Yes | 11 [31%] | 3 [20%] | 0.412 [Z test] |
No | 17 [49%] | 12 [80%] | 0.039 [Z test] |
Data not available | 7 [20%] | 0 [0%] | 0.061 [Z test] |
Smoking status | 0.779 [overall chi 2 ] | ||
Active/history | 22 [63%] | 10 [59%] | 0.281 [Z test] |
Non-smoker | 13 [37%] | 7 [41%] | 0.281 [Z test] |
Operation type | |||
Ileocolic resection | 20 [57%] | N/A | N/A |
Ileocolic resection + other | 1 [3%] | N/A | N/A |
Ileocolic resection + defunction | 1 [3%] | N/A | N/A |
Small bowel resection | 2 [6%] | N/A | N/A |
Sigmoid colectomy | 1 [3%] | N/A | N/A |
Panproctocolectomy | 2 [6%] | N/A | N/A |
Washout | 1 [3%] | N/A | N/A |
Adhesiolysis | 1 [3%] | N/A | N/A |
Defunction | 6 [16%] | N/A | N/A |
Total colectomy | N/A | 11 [69%] | N/A |
Completion proctecomy | N/A | 5 [31%] | N/A |
Medications at time of surgery | 28 [80%] | 13 [77%] | 0.925 [overall chi 2 ] |
Aminosalicylates | 9 [26%] | 7 [41%] | 0.222 [chi2 test] |
Steroid | 14 [40%] | 6 [35%] | 0.804 [chi2 test] |
Antibiotics | 3 [9%] | 4 [24%] | 0.124 [chi2 test] |
Immunosuppressants | 8 [29%] | 3 [18%] | 0.704 [chi2 test] |
Thiopurines | 7 [20%] | 3 [18%] | 0.842 [z test] |
Methotrexate | 1 [3%] | 0 [0%] | 0.484 [Z test] |
Biologics | 16 [46%] | 10 [59%] | 0.308 [chi2 test] |
anti-TNF | 15 [43%] | 9 [53%] | 0.497 [Z test] |
anti-α 4β 7 | 1 [3%] | 1 [6%] | 0.596 [Z test] |
None | 6 [17%] | 3 [18%] | 0.412 [chi2 test] |
Data not available | 1 [3%] | 1 [6%] | 0.412 [chi2 test] |
Montreal Classification of disease | |||
Age at diagnosis | 0.591 [overall chi 2 ] | ||
A1 ≤16 years old | 2 [6%] | 0 [0%] | 0.347 [Z test] |
A2 = 17–40 years old | 24 [69%] | 8 [53%] | 0.303 [Z test] |
A3 >40 years old | 8 [29%] | 4 [27%] | 0.772 [Z test] |
Data not available | 1 [3%] | 1 [7%] | 0.529 [Z test] |
Location | |||
L1 Terminal ileum | 19 [54%] | N/A | N/A |
L2 Colonic | 3 [9%] | N/A | N/A |
L3 Ileocolic | 7 [20%] | N/A | N/A |
L4 Upper GI | 4 [11%] | N/A | N/A |
L1 + L4 | 1 [3%] | N/A | N/A |
E1 proctitis | N/A | 1 [7%] | N/A |
E2 left-sided colitis | N/A | 6 [40%] | N/A |
E3 pan- | N/A | 8 [53%] | N/A |
Data not available | 1 [3%] | N/A | N/A |
Disease behaviour | |||
B1 non-stricturing, non-penetrating | 5 [14%] | N/A | N/A |
B2 stricturing | 14 [40%] | N/A | N/A |
B3 penetrating | 15 [43%] | N/A | N/A |
P perianal involvement | 3 [9%] | N/A | N/A |
Data not available | 1 [3%] | N/A | N/A |
Data are presented as mean ± SE. Bold text indicates statistically significant results. Italicised and underlined text indicates results for overall statistical tests. Biologic medication consists of anti-tumour necrosis factor [TNF] [adalimumab, infliximab, certolizumab, or golimumab] or anti-α 4β 7 integrin [vedolimumab] agents.
CD, Crohn’s disease; UC,ulcerative colitis; GI, gastrointestinal; N/A, not available.