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. 2019 Jun 15;14(1):79–95. doi: 10.1093/ecco-jcc/jjz115

Figure 8.

Figure 8.

CD163− MNPs increase IL-8 expression in colonic CD4+ T cells in UC but not CD patients. CD4+ T cells isolated from inflamed UC or CD colons were co-cultured with or without: [a] autologous mucosal CD163− cells [n = 17 UC, n = 14 CD] and stained for IL-8 intracytoplasmic expression; [b] autologous mucosal CD163+ [n = 4] or CD163− cells [n = 17] and stained for IL-8, IL-17 and IFN-γ intracytoplasmic expression; and [c] autologous CD163− cells [n = 17], in the absence or presence of αIL-1β [n = 4] and/or αIL-12p70 mAbs [n = 4], and stained for IL-8, IL-17 and IFN-γ intracytoplasmic expression. [a–c, left panel] Wilcoxon signed rank test; for b, p < 0.01 threshold for significance to account for test multiplicity. [c, right panel] Repeated measures ANOVA with Bonferroni’s multiple comparison post test.