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. Author manuscript; available in PMC: 2020 May 25.
Published in final edited form as: Nat Med. 2019 Nov 25;25(12):1858–1864. doi: 10.1038/s41591-019-0650-9

Extended Data Figure 2. Timecourse of RNA-Seq data upon antibiotic exposure reveals differential gene expression between susceptible and resistant clinical isolates.

Extended Data Figure 2.

Susceptible (left panels) or resistant (right panels) clinical isolates of K. pneumoniae, E. coli, or A. baumannii treated with meropenem, ciprofloxacin, or gentamicin at CLSI breakpoint concentrations for the indicated times. Data are presented as MA plots, Statistical significance was determined by a two-sided Wald test with the Benjamini-Hochberg correction for multiple hypothesis testing, using the DESeq2 package47.