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Visual representations of different approaches to address the cell permeability challenge associated with developed DUB ABPs. (A) Family tree for DUBs, parenthesis displays how many enzymes are in this sub-family, (B) Pore-forming toxins, (C) Electroporation, (D) Cell penetrating peptide-based DUB ABPs (E) Activity-based protein profiling with small molecule-based DUB ABPs—(F) Small molecule DUB inhibitors from the literature that have been converted to ABPs.
