Table 4.

The most significant differently expressed biological pathways examined with KEGG database (P < 0.05) in the distal region of the uterine horn endometrium 6 days after heterologous seminal plasma (SP) or Beltsville Thawing Solution (BTS; control) infusions prior to insemination.

	Pathway ID	Pathway name	Enrichment Score	Genes altered (%)	Gene list*
1	Map04514	Cell adhesion molecules (CAMs)	1.6	4.7	PECAM1, SLA-8, VCAN, CLDN25, CD274, PTPRF, VTCN1
2	Map04110	Cell cycle	2.3	6.2	ATR, ANXA1, BACH1, CRLF3, DLG1, HECA, IRF1, LIN52, ORC4, PPP1CB, SLC26A8, STAG2, STAT5A, USP37, ZPR1, ADCYAP1, CABLES2, CHEK1, MIIP, PPP2CA, TAF2, TRIM35
3	Map04050	Cytokine-cytokine receptors interaction	0.2	2.6	ACVR2, CRLF3, FAS, IL13, CSF3, CXCR3, IL5, IL10RA, MAP10
4	Map04915	Estrogen signaling	0.9	3.9	GRB2, SOS1, ADCY4, ATF6B, GNAS, NRAS
5	Map04510	Focal adhesion	0.1	2.2	GRB2, MRLC2, PPP1CB, FIGF, ITGA2B
6	Map04912	GnrH signaling	0.9	4	GRB2, SOS1, ADCY4, GNAS, NRAS
7	Map04913	Ovarian steroidogenesis	1	4.6	INSR, ADCY4, GNAS
8	Map04151	PI3K-Akt signaling	0.4	3	GRB2, INSR, LPAR1, RHEB, SOS1, PPP2R3A, CSF3, NRAS, ATF6B
9	Map04011	MAPK-ERK signaling	2.3	8.6	FAS, SOS1, DLG1, GRB2, LPAR1, PDCD10, RNF149, NRAS, F2RL1, INHBE
10	Map04917	Prolactin signaling	3.7	8	GRB2, IRF1, SOCS5, SOCS6, STAT1, STAT5A, NRAS
11	Map04660	T-Cell receptor signaling	0.8	3.7	DLG1, GRB2, NFKBIA, IL5, NRAS
12	Map04350	TGF-beta signaling	0.6	3.4	ACVR2, INHBE, PPP2CA
13	Map04620	Toll-like receptor signaling	1.2	4.4	LY96, NFKBIA, RIPK1, STAT1, IRAK1, TAB1
14	Map04370	VEGF signaling pathway	0.1	1.3	NRAS
15	Map04310	Wnt signaling	0.2	2.1	CSNK2A2, VANGL2, GRB10, KLH212, RYK, STRN, TSC2, PTPRO, SHISA2
16	MAP04630	Jak-Stat signaling pathway	1.4	4.4	CSF3, GRB2, IL5, IL10RA, IL13, SOCS5, STAT1, STAT5A

^*Up-regulated and down-regulated genes are marked by bold and regular font, respectively.