Table 5.

The most significant differently expressed biological pathways examined with KEGG database (P < 0.05) in the proximal region of the uterine horn endometrium collected 6 days after heterologous seminal plasma (SP) or Beltsville Thawing Solution (BTS; control) infusions prior to insemination.

	Pathway ID	Pathway name	Enrichment Score	Genes altered (%)	Gene list*
1	Map04514	Cell adhesion molecules (CAMs)	0.2	1.2	LRRC4C, PVRL1
2	Map04110	Cell cycle	1.6	3.2	CCNE1, RB1, SMAD4, TP53
3	Map04050	Cytokine-cytokine receptors interaction	0.2	1.3	PDGFA, CCR1, CD70, LEP
4	Map04915	Estrogen signaling	2.4	3.9	GNAS, PIK3R5, NRAS, PIK3R2, SRC
5	Map04510	Focal adhesion	1.5	2.7	PDGFA, PIK3R5, ELK1, IGF1R, PIK3R2, SRC
6	Map04912	GnrH signaling	2.2	4	GNAS, ELK1, NRAS, SRC
7	Map04913	Ovarian steroidogenesis	1.1	3.1	GNAS, IGF1R
8	Map04151	PI3K-Akt signaling	2.8	3	CDC37, FGF14, PDGFA, PIK3R5, CCNE1, CRTC2, GYS1, IGF1R, JAK3, NRAS, PIK3R2, TP53
9	Map04917	Prolactin signaling	2.6	4.6	PIK3R5, NRAS, PIK3R2, SRC
10	Map04660	T-Cell receptor signaling	1.4	3	PIK3R5, CD247, NRAS, PIK3R2
11	Map04350	TGF-beta signaling	0.2	1.1	SMAD4
12	Map04620	Toll-like receptor signaling	0.3	1.5	PIK3R5, PIK3R2
13	MAP04370	VEGF signaling pathway	3	5.3	PIK3R5, NRAS, PIK3R2, SRC
14	Map04310	Wnt signaling	0.7	2.1	SMAD4, CSNC2B, TP53
15	Map04630	Jak-Stat signaling pathway	0.9	2.2	JAK3, LEP, PIK3R2, PK3R5

^*Up-regulated and down-regulated genes are marked by bold and regular font, respectively.