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. 2019 Dec 18;7:341. doi: 10.3389/fcell.2019.00341

FIGURE 4.

FIGURE 4

(A) Conservation of C-terminus of PPP1CC2 in mammals. The 5′ and 3′ splice sites for the generation of PP1γ2 in Ppp1cc is found only in mammals. These splice sites and a recognizable exon 8 are absent in Ppp1cc in the genomes of the duck billed platypus and the non-mammalian vertebrates. The C-terminal 22 amino acid residues (316–337) are virtually identical in all placental mammals for which annotated genomic data bases exist. Sequences from a few of these mammals are shown above. (B) PKA catalytic subunit in somatic cells (Cα1) and sperm (Cα2) are derived from alternate exons 1a and 1b. Cα1 is present in somatic cell. Cα2 produced in testis using exon 1b is present only in mammals. Exon 1b is present and conserved in all placental mammals. (C) Conservation of GSK3α isoform in mammals. The glycine rich N-terminus of the GSK3 alpha isoform is conserved in placental mammalian species, but not in non-mammalian vertebrates. (D) Conservation of testis-specific isoform of PP2B, PPP3R2 (regulatory subunit) across different mammalian species. While the entire PPP3R2 is present and conserved in all mammals only a portion of the N-terminus sequence of PPP3R2 is shown.