TABLE 2.
The binding profile of the regulators with PP1γ2 in caput and caudal epididymal sperm is summarized in the table along with data with caudal sperm from Gsk3α knockout, PKA Cα2 knockout and sAC knockout mice where the binding status of sds22 resembles that in wild type caput sperm.
| Group |
 Mouse lines
|
I2 | SDS22 | I3 | |
| 1 | Wild type (Goswami et al., 2019) | Caput | Not bound | Not bound | Bound |
| Caudal | Bound | Bound | Bound | ||
| 2 | GSK3α global knockout (Goswami et al., 2019) | Caput | Not bound | Not bound | Bound |
| Caudal | Bound | Not bound | Bound | ||
| 3 | PKACα2 (testis isoform specific) knockout (Goswami, 2018) | Caput | Not bound | Not bound | Bound |
| Caudal | Bound | Not bound | Bound | ||
| 4 | sAC (Adcy10) knockout (Goswami et al., 2019) | Caput | Not bound | Not bound | Bound |
| Caudal | Bound | Not bound | Bound |
Thus, epididymal sperm maturation appears to be altered in these knockout mice.