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. 2019 Dec 24;9:19771. doi: 10.1038/s41598-019-56337-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Illustrative diagram of 21 ellipsoid zone (EZ) retinal locations and sampling of external limiting membrane (ELM) at fovea and to maximum of 2000 µm eccentricity from fovea, vertically. Each sample was 150 μm wide and had intervals of 200 μm. Accordingly, an EZ segment’s “relative intensity” was calculated by dividing the EZ segment intensity by the ELM intensity. The retinal segment (I-3) that was used for the relative EZ intensity calculation is marked by an asterisk.