Table 2.
Significantly regulated genes in PPD-stimulated PBMCs in pair-wise comparisons validated in test set from Biomarker Identification Cohort by qRT-PCR.
| Gene symbol | Mean fold change | Ratio | Mann-Whitney U | |
|---|---|---|---|---|
| ATB/LTBI | ATB | LTBI | ATB/LTBI | P-value |
| IFNG | 6.63 | 2.07 | 3.20 | 0.0341 |
| PGM5 | 3.71 | 1.03 | 3.60 | 0.0213 |
| EBF3 | 3.10 | 0.71 | 4.37 | 0.0151 |
| TNFRSF10C | 0.15 | 1.49 | 0.10 | <0.0001 |
| A2ML1 | 1.82 | 0.52 | 3.50 | 0.0434 |
| ATB/CON | ATB | CON | ATB/CON | P-value |
| IFNG | 2.07 | 0.71 | 2.91 | 0.0115 |
| CXCL10 | 4.43 | 0.55 | 7.99 | 0.0185 |
| TNFRSF10C | 0.15 | 0.47 | 0.33 | 0.0420 |
| ENPP3 | 2.54 | 0.53 | 4.75 | 0.0321 |
| MYBPH | 4.97 | 0.78 | 6.39 | 0.0124 |
| IL26 | 0.73 | 0.22 | 3.38 | 0.0403 |
| GPR146 | 0.26 | 1.25 | 0.21 | 0.0321 |
| VCAN | 0.32 | 0.87 | 0.37 | 0.0476 |
| GPRC5A | 4.61 | 1.05 | 4.39 | 0.0436 |
| GPR64 | 0.81 | 2.45 | 0.33 | 0.0414 |
| A2ML1 | 1.82 | 0.58 | 3.13 | 0.0488 |
| EBF3 | 3.1 | 0.64 | 4.84 | 0.0231 |
| LTBI/CON | LTBI | CON | LTBI/CON | P-value |
| CD1A | 3.21 | 0.85 | 3.78 | 0.0325 |
| HBEGF | 10.93 | 1.74 | 6.30 | 0.0021 |
| ZBED2 | 3.80 | 1.15 | 3.32 | 0.0263 |
| HCAR2 | 5.44 | 1.39 | 3.92 | 0.0302 |
| PDSS1 | 6.73 | 2.35 | 2.86 | 0.0412 |
| KCNJ10 | 0.21 | 0.72 | 0.30 | 0.0485 |
| IFNG | 6.63 | 0.71 | 9.32 | 0.0051 |
| CXCL10 | 4.36 | 0.55 | 7.87 | 0.0134 |
| TNFRSF10C | 1.49 | 0.47 | 3.20 | 0.0355 |
Fold change: the fold change was calculated by dividing gene expression level of PPD-stimulated sample by gene expression level of unstimulated sample by qRT-PCR.
Ratio: the ratio was calculated by dividing mean fold change of one group by mean fold change of another group.