Figure 4.

DA-induced inhibition on the firing of NAc-projecting VTA DA neurons is reduced in the social defeat model of mice. (A,B) Example traces from cell-attached recordings of NAc-projecting VTA DA neurons are shown before and after administration of fasudil (a selective Kv7.4 opener; 10 μM) and DA (20 μM) in the control and the social defeat model mice. (C) Summarized the effect of fasudil and DA on the spontaneous firing frequency of NAc-projecting VTA DA neurons. **p < 0.01, *p < 0.05; N.S., not significant, paired t-test. N = number of animals; n = number of recordings. (D) Normalized firing frequency based on the data shown in C. Error bars represent SEM. **p < 0.01, *p < 0.05; N.S., not significant, one-sample Wilcoxon signed ranks test.