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. 2019 Dec 24;9:19766. doi: 10.1038/s41598-019-56489-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Pseudo-color images of D (A), D* (B) and f (C) value in IVIM-DWI images in the same 56-year-old man as in Fig. 1. (A) The D value of the infarction (white arrows) of the interventricular septum was significantly lower than that (arrow head) of the normal lateral wall myocardium. (B) The D* value of the infarction (white arrows) of the interventricular septum was significantly greater than that (arrow head) of the normal lateral wall myocardium. (C) The f value of the infarction of the interventricular septum was significantly greater than that of the normal lateral wall myocardium. The D, D* and f values of the infarction of the interventricular septum were 0.0016 × 10⁻³ mm²/s, 0.79 × 10⁻³ mm²/s and 0.14, respectively. (D) In the fitting curves, the measured signal intensity points are distributed near the fitted curves, which reflect a higher image quality without obvious impact by respiratory movement and heart beat. Meanwhile, the dual-exponential algorithm demonstrates a better fitting effect than mono-exponential algorithm. D value, diffusion coefficient; D* value, perfusion coefficient; f value, perfusion fraction; IVIM, intravoxel incoherent motion; DWI, diffusion-weighted image.