Table 1.
Clinical characteristics of patients with amniocentesis.
| Patients with IAI (n = 34) | Normal controls (n = 14) | p-value | |
|---|---|---|---|
| Maternal age (years) | 33 [30.8–36.0] | 36.5 [33.8–38.5] | 0.005 |
| Previous preterm delivery | 5 (14.7) | 1 (7.1) | 0.656 |
| Gestational age at amniocentesis (weeks) | 21.0 [19.6–22.4] | 17.4 [16.7–19.9] | <0.001 |
| Gestational age at delivery (weeks) | 29.4 [21.0–38.0] | 38.0 [37.0–38.5] | 0.002 |
| Maternal WBC count (cell/mL) | 9,750 [8,375–12,350] | 8,885 [7,395–11,012] | 0.353 |
| Amniotic fluid analysis | |||
| HMGB1 (pg/mL) | 563.8 [373.0–800.0] | 273.0 [47.0–539.3] | 0.004 |
| IL-6 (pg/mL) | 6,022 [5,199–6,224] | 588 [465–1,175] | <0.001 |
| Glucose < 20 mg/dL, n (%) | 10 (29.4) | 0 | 0.023 |
| WBC (cells/mm3) | 40 [7.0–137.5] | 7.0 [2.0–9.3] | 0.019 |
| Positive cultures | 2 (5.9) | 0 | 1.000 |
Data presented as median [interquartile range] or n (%).
IAI, intra-amniotic inflammation; WBC, white blood cell; HMGB1, High mobility group box 1; IL-6, interleukin-6.