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. 2019 Dec 24;9:19748. doi: 10.1038/s41598-019-56242-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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AGE are increased in diabetic human adipose tissue. (a) Representative fluorescence microscopy images and (b) quantified mean relative fluorescence intensity units (RFU) of AGE expression in human DM and NDM VAT and SAT. Bars with different letters indicate P < 0.050 in multiple comparison analysis. (c,d) Association of VAT or SAT AGE fluorescence intensity and serum HbA1c percentage for entire cohort. Linear model b value (b), standard error (SE) and P-values shown are unadjusted and adjusted for age and sex. VAT: n = 21 NDM, 19 DM subjects; SAT: n = 13 NDM, 12 DM subjects.