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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: J Autoimmun. 2019 Aug 2;106:102306. doi: 10.1016/j.jaut.2019.102306

Figure 7.

Figure 7.

Solvent accessibility and chemical modification determine the buried nature of MPO447–461. (A) Accessibility to solvent of each amino acid in MPO447–459 determined by predictive algorithms. Residues are considered to be solvent exposed if ratio value > 50%, and buried if the ratio value < 20%. (B) Isotope labeling with succinic anhydride to determine solvent accessibility of MPO epitopes. The top panel examines the percentage of succinylation versus the accessibility of ε-NH2 Lysine and N-terminal α-NH2. MPO447–461 ((R)KIVGAMVQIITYR(D)), represented by the circled data point, had almost undetectable levels of succinylation and solvent accessibility.