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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Hum Mutat. 2019 Oct 26;41(1):316–331. doi: 10.1002/humu.23930

Figure 7.

Figure 7.

A two-dimensional representation of HCO3−/Cl− and I−/Cl− antiport activities (the slope values provided in Table 1) determined in this study for WT (indicated by blue diamond) and 51 pendrin missense variants. The error bars indicate the standard errors associated with linear regressions. F-tests were performed to objectively assess the pathological effects of the pendrin variants (see the main text for detail). Note that p.Gly334Val (c.1001G>T) was found to disrupt mRNA splicing (Fig. 6).