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. 2019 Dec 20;12:11325–11338. doi: 10.2147/OTT.S231846

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© 2019 Wang et al.

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Serum exosomal HOTTIP was associated with cisplatin resistance in GC patients. (A) Serum exosome HOTTIP level was measured in patients responding or not responding to cisplatin treatment by qRT-PCR. (B-D) Exosomal HOTTIP expression level was assessed using qRT-PCR analysis in the long exposure, RNase A digestion, and low or high pH solution, respectively. (E) The diagnostic value of exosomal HOTTIP in GC patients receiving cisplatin treatment was analyzed by ROC curve. (F) The proportion of patients not responding or responding to cisplatin was analyzed in patients with high or low HOTTIP level. *P<0.05.