Table 2.
Markers | AUC | 95% CI | Sensitivity | ||
---|---|---|---|---|---|
90% specificity | 95% CI | Cut off | |||
Breast cancer versus normal control | |||||
miR-193b-5p | 0.762*** | 0.674-0.851 | 34.48% | 0.225-0.481 | 1.23 |
CEA | 0.567 | 0.463-0.672 | 15.52% | 0.073-0.274 | 3.15 |
CA15-3 | 0.552 | 0.447-0.658 | 17.91% | 0.050-0.233 | 17.91 |
miR-193b-5p+CEA | 0.773*** | 0.687-0.860 | 25.86% | 0.153-0.391 | |
miR-193b-5p+CA15-3 | 0.767*** | 0.680-0.854 | 27.59% | 0.167-0.409 | |
CEA+CA15-3 | 0.583 | 0.489-0.688 | 17.24% | 0.086-0.294 | |
Breast cancer versus benign disease | |||||
miR-193b-5p | 0.770*** | 0.677-0.863 | 60.34% | 0.466-0.730 | 2.49 |
CEA | 0.516 | 0.395-0.638 | 11.11% | 0.031-0.261 | 0.86 |
CA15-3 | 0.506 | 0.388-0.624 | 16.17% | 0.086-0.294 | 16.2 |
miR-193b-5p+CEA | 0.738** | 0.638-0.840 | 34.48% | 0.225-0.482 | |
miR-193b-5p+CA15-3 | 0.760*** | 0.662-0.859 | 58.62% | 0.449-0.714 | |
CEA+CA15-3 | 0.525 | 0.404-0.646 | 18.97% | 0.099-0.314 |
**P<0.01; ***P <0.001