Table 4.
Immunohistochemical and genetic features of the 16 DLBCL and FL cases
| No. | Diagnosis | BCL2 | BCL6 | C-MYC | Ki67 | IgH | |||
|---|---|---|---|---|---|---|---|---|---|
| IHC | FISH | IHC | FISH | IHC | FISH | IHC | FISH | ||
| Case 1 | FL | positive | T&G | positive | x | x | G (3- 4 cp) | x | x |
| Case 2 | FL | positive | T | positive | N | x | G (up to 3 cp) | >80 | T |
| Case 3 | FL | positive | T | positive | T | x | N | 50 | T |
| Case 4 | DLBCL | >70% | G (up to 3 cp) | <50% | G (3- 4 cp) | <40% | N | >90 | x |
| Case 5 | DLBCL | >70% | G (2- 3 cp) | <50% | T | <40% | N | >90 | N |
| Case 6 | DLBCL | >70% | N | <50% | T | <40% | T | 40 | T |
| Case 7 | DLBCL | >70% | G (3- 4 cp) | >50% | G (3- 4 cp) | >40% | G (3- 4 cp) | 50 | G (3- 4 cp) |
| Case 8 | DLBCL | >70% | G (up to 3 cp) | ~50% | x | <40% | T | >80 | x |
| Case 9 | DLBCL | >70% | G (2- 3 cp) | >50% | N | >40% | T | ~50 | N |
| Case 10 | DLBCL | >70% | G (3- 4 cp) | ~50% | T&G | <40% | N | >95 | N |
| Case 11 | DLBCL | >70% | G (3- 4 cp) | >50% | G (2- 3 cp) | >40% | N | 90 | N |
| Case 12 | DLBCL | >70% | G (4- 5 cp) | >50% | G (up to 3 cp) | >40% | G (up to 3 cp) | ~100 | N |
| Case 13 | DLBCL | >70% | G (4- 5 cp) | >50% | T&G | >40% | G (3- 4 cp) | ~100 | T&G |
| Case 14 | DLBCL | >70% | T | >50% | T | <40% | G (3- 4 cp) | >90 | T |
| Case 15 | DLBCL | ~70% | G (5- 6 cp) | <50% | G (up to 3 cp) | >40% | G (3- 4 cp) | x | T&G |
| Case 16 | DLBCL | >70% | G (3- 5 cp) | ~50% | T&G | <40% | N | 80 | N |
N, Normal; G, Gain copies; T, Translocation; T&G, Translocation & Gain copies; cp, copies; X, Missing/No tissue left