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. 2020 Jan 1;11(1):83–91. doi: 10.7150/jca.36495

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GSTA1 decreased in HCC. A. GSTA1 is downregulated in HCC tumor tissues compared with para-tumor tissues, calculated by Image Pro Plus (IPP) Image Analysis Software (**P < 0.01). B. the protein level of GSTA1 is related to pathological differentiation of HCC. GSTA1 was highly expressed in well-differentiated HCC tumors, but decreased heavily and was almost absent in poorly differentiated tumor tissues. Representative photomicrographs showed immunostaining of GSTA1 in well (Left), moderately (Middle) and poorly (Right) differentiated HCC specimens (magnification, 50×, 200×, 400×). C. Deficiency of GSTA1 was detected in liver cancer cell lines, including HCC-LM3 MHCC-97H, SK-Hep1, SMMC-7721 and SNU-449, but not in HepG2 and PLC-PRF5, checked by western blot.