Table 1.
Multivariable analysis of six membrane protein genes in TCGA cohort.
| HR (95% CI)/(p-value) | ||||||
|---|---|---|---|---|---|---|
| OS Covariate | CD52 | CD96 | EMP1 | TSPAN2 | STAB1 | MBTPS1 |
| Age | 2.42 | 2.59 | 2.36 | 2.25 | 2.44 | 1.59 |
| (1.13-3.67) /(p=0.013) | (1.27-3.99)/(p=0.0011) | (1.07-3.51)/(p=0.0104) | (1.03-3.32)/(p=0.0172) | (1.15-3.62)/(p=0.0147) | (1.04-3.18)/(p=0.0077) | |
| DNMT3A | 1.45 | 2.63 | 2.21 | 2.53 | 2.20 | 2.07 |
| (0.69-2.45)/(p=0.1053) | (1.27-3.96)/(p=0.1008) | (1.07-3.43)/(p=0.018) | (1.08-4.16)/(p=0.0069) | (1.07-3.50)/(p=0.028) | (1.02-3.27)/(p=0.019) | |
| RUNX1 | 1.91 | 2.14 | 1.97 | 1.82 | 2.04 | 1.91 |
| (0.92-3.06)/(p=0.0329) | (1.09-5.82)/(p=0.0488) | (0.78-4.39)/(p=0.1763) | (0.79-4.83)/(p=0.0574) | (1.03-5.37)/(p=0.0417) | (0.88-4.57)/(p=0.0407) | |
| FLT3-ITD | -1.47 | 0.64 | 1.74 | 1.53 | 1.59 | 1.57 |
| (0.12-1.23)/(p=0.1377) | (0.67-2.48)/(p=0.5326) | (0.86-3.13)/(p=0.0517) | (0.79-3.01)/(p=0.1103) | (0.89-3.07)/(p=0.1124) | (0.77-2.97)/(p=0.1074) | |
| MT-CYB | 1.76 | 1.71 | 1.25 | 1.04 | 1.33 | 1.32 |
| (0.93-4.57)/(p=0.0729) | (0.82-10.94)/(p=0.1338) | (0.63-8.51)/(p=0.3494) | (0.53-7.42)/(p=0.2805) | (0.66-8.75)/(p=0.185) | (0.58-7.75)/(p=0.175) | |
| WT1 | 1.54 | 0.77 | 0.72 | 0.57 | 0.16 | 0.17 |
| (0.67-10.11)/(p=0.1203) | (0.58-3.92)/(p=0.4993) | (0.53-3.95)/(p=0.4718) | (0.48-3.60)/(p=0.5357) | (0.44-5.02)/(p=0.2461) | (0.43-4.92)/(p=0.2031) | |
| IDH2 | 0.07 | 0.021 | 0.43 | 0.52 | -0.47 | -0.46 |
| (0.43-2.26)/(p=0.9125) | (0.51-2.48)/(p=0.098) | (0.53-2.65)/(p=0.4344) | (0.56-2.57)/(p=0.5327) | (0.56-1.85)/(p=0.638) | (0.55-1.75)/(p=0.535) | |
| NPM1 | 0.68 | 0.19 | 0.16 | 0.19 | -0.05 | -0.04 |
| (0.52-3.79)/(p=0.4357) | (0.59-2.01)/(p=0.8976) | (0.51-1.86)/(p=0.817) | (0.57-2.07)/(p=0.7654) | (0.53-1.85)/(p=0.963) | (0.51-1.82)/(p=0.768) | |
| IDH1 | -0.23 | -1.47 | -1.31 | -1.43 | -1.28 | -1.18 |
| (0.41-1.67)/(p=0.7176) | (0.13-1.23)/(p=0.1287) | (0.2-1.28)/(p=0.144) | (0.12-1.27)/(p=0.145) | (0.16-1.4)/(p=0.2016) | (0.14-1.2)/(p=0.1789) | |
| Total | 2.4 | 2.5 | 2.2 ( | 1.8 | 1.98 | 0.56 |
| (1.2-4.8)/(p=0.013) | (1.2-5.2)/(p=0.016) | 1.2-4.1)/(p=0.018) | (1-3.3)/(p=0.041) | (1.01-3.03)/(p=0.0473) | (0.32-0.98)/(p=0.041) | |
The model was generated from a Cox regression model that included Age, gene mutation of DNMT3A, and RUNX1, FLT3-ITD, MT-CYB, WT1, IDH2, NPM1, IDH1 and expression level of each membrane protein gene. HR: Hazard Ratio.