Table 2.
Korean gastric cancer patients with CDH1 V832M germline mutation identified in this study
| ID | Sex | Age at diagnosis | Lauren's classification | WHO classification | TNM classification | EBV infectiona | MSI stateb | H. pylori infectionc | Family history of cancer (affected family member) | Other cancer histories in a patient (age at diagnosis) |
|---|---|---|---|---|---|---|---|---|---|---|
| P41 | F | 50 | Diffuse | Poorly cohesive | Stage IA | Negative | MSS | Negative | None | Papillary thyroid cancer (49) |
| P93 | F | 58 | Intestinal | Tubular | Stage IA | Negative | MSS | Not done | Colon cancer (a brother) | None |
| P119 | M | 62 | Intestinal | Tubular | Stage IIIA | Positive | MSS | Not done | None | None |
| P143 | F | 66 | Intestinal | Tubular | Stage IIA | Negative | MSI-H | Not done | Lymphoma (a son) | None |
| P154 | M | 66 | Intestinal | Tubular | Stage IIB | Negative | MSS | Positive | Unknown | Unknown |
| P186 | M | 41 | Intestinal | Tubular | Stage IA | Negative | MSS | Negative | Gastric cancer (a father) | None |
| P253 | M | 75 | Diffuse | Tubular | Stage IIB | Negative | MSI-H | Negative | Unknown | Unknown |
EBV, Epstein-Barr virus; MSI, microsatellite instability; H. pylori, Helicobacter pylori; MSS, microsatellite stability; MSI-H, microsatellite instability high. aEBV infection was detected using in-situ hybridization or real-time PCR. bMicrosatellite instability status was determined by the mononucleotide repeat markers NR-21, BAT-26, BAT-25, NR-24, and NR-27. MSI-H was defined as a tumor with two or more of the five markers of instability, and MSS was defined as the absence of any marker. cH. Pylori infection was detected using Giemsa stain or PCR and sequencing.