Table 4.
Association of the CDH1 V832M germline mutation and phenotypes in gastric cancer patients
| Variables | V832M heterozygotes (N=7)a | V832M non-carrier (N=298)a | P valueb | |
|---|---|---|---|---|
| Age (years) | 62 (54, 66) | 64 (54,74) | 0.477 | |
| Sex | 0.708 | |||
| Female | 3 (42.9%) | 108 (36.2%) | ||
| Male | 4 (57.1%) | 190 (63.8%) | ||
| Lauren's classification | >0.999 | |||
| Diffuse/mixed type | 2 (28.6%) | 76 (25.5%) | ||
| Intestinal type | 5 (71.4%) | 222 (74.5%) | ||
| Family history of gastric cancerc | >0.999 | |||
| Presence (one or more family members) | 1 (20.0%) | 36 (18.7%) | ||
| Absence | 4 (80.0%) | 157 (81.3%) | ||
| Age of cancer diagnosis | 0.507 | |||
| Early-onset (≤45 years) | 1 (14.3%) | 28 (9.4%) | ||
| Late-onset (>45 years) | 6 (85.7%) | 270 (90.6%) | ||
| Other cancer histories in a patientc | 0.290 | |||
| Presence | 1 (20.0%) | 12 (6.2%) | ||
| Absence | 4 (80.0%) | 181 (93.8%) | ||
aResults are expressed as median (interquartile ranges) or number (%). bThe P values were calculated by Mann-Whitney U test for continuous variables and Fisher's exact test for categorical variables. cFamily history of gastric cancer and other cancer history in a patient were assessed in 198 patients.