Table 5.
Association of the three SNPs with lung cancer risks and non-small-cell lung cancer risks in female and male populations.
| Genotype | Gender | Controls (%)(582) |
Lung cancer | Non-small cell lung cancer | ||||
|---|---|---|---|---|---|---|---|---|
| Case(%)(515) | ORa(95%CI) | Pb-value | Cases(%)(454) | ORa(95%CI) | Pb-value | |||
| Rs2608053 | ||||||||
| GG | Female | 151(53.5) | 121(49.6) | 1.00 (ref) | 108(48.2) | 1.00 (ref) | ||
| AG | 111(39.4) | 107(43.9) | 1.249(0.862-1.809) | 0.240 | 101(45.1) | 1.339(0.916-1.958) | 0.131 | |
| AA | 20(7.1) | 16(6.6) | 1.169(0.577-2.368) | 0.664 | 15(6.7) | 1.246(0.607-2.559) | 0.549 | |
| AG+AA vs GG | 1.237(0.867-1.765) | 0.241 | 1.325(0.920-1.909) | 0.130 | ||||
| AA vs AG+GG | 1.058(0.533-2.098) | 0.873 | 1.089(0.542-2.187) | 0.811 | ||||
| GG | Male | 177(59.0) | 162(59.8) | 1.00 (ref) | 134(58.3) | 1.00 (ref) | ||
| AG | 109(36.3) | 95(35.1) | 0.986(0.677-1.436) | 0.941 | 84(36.5) | 1.034(0.701-1.524) | 0.868 | |
| AA | 14(4.7) | 14(5.2) | 1.304(0.562-3.026) | 0.536 | 12(5.2) | 1.312(0.549-3.132) | 0.541 | |
| AG+AA vs GG | 1.019(0.709-1.463) | 0.920 | 1.062(0.730-1.544) | 0.752 | ||||
| AA vs AG+GG | 1.311(0.572-3.005) | 0.522 | 1.295(0.550-3.049) | 0.555 | ||||
| Rs1561927 | ||||||||
| AA | Female | 261(92.6) | 223(91.4) | 1.00 (ref) | 205(91.5) | 1.00 (ref) | ||
| AG | 21(7.4) | 21(8.6) | 1.334(0.702-2.536) | 0.379 | 19(8.5) | 1.294(0.670-2.500) | 0.443 | |
| GG | 0(0.0) | 0(0.0) | - | - | 0(0.0) | - | - | |
| AG+GG vs AA | 1.334(0.702-2.536) | 0.379 | 1.294(0.670-2.500) | 0.443 | ||||
| GG vs AG+AA | - | - | - | - | ||||
| AA | Male | 286(95.3) | 256(94.5) | 1.00 (ref) | 216(93.9) | 1.00 (ref) | ||
| AG | 14(4.7) | 14(5.2) | 1.381(0.608-3.319) | 0.441 | 14(6.1) | 1.585(0.700-3.588) | 0.269 | |
| GG | 0(0.0) | 1(0.4) | - | - | 0(0.0) | - | - | |
| AG+GG vs AA | 1.460(0.651-3.274) | 0.358 | 1.585(0.700-3.588) | 0.269 | ||||
| GG vs AG+AA | - | - | - | - | ||||
| Rs13254990 | ||||||||
| CC | Female | 183(64.9) | 168(68.9) | 1.00 (ref) | 155(69.2) | 1.00(ref) | ||
| CT | 91(32.3) | 64(26.2) | 0.687(0.460-1.025) | 0.066 | 59(26.3) | 0.691(0.458-1.042) | 0.078 | |
| TT | 8(2.8) | 12(4.9) | 1.223(0.455-3.289) | 0.689 | 10(4.5) | 1.176(0.423-3.265) | 0.756 | |
| CT+TT vs CC | 0.730(0.497-1.073) | 0.109 | 0.731(0.493-1.083) | 0.118 | ||||
| TT vs CT+CC | 1.369(0.513-3.650) | 0.530 | 1.313(0.476-3.617) | 0.599 | ||||
| CC | Male | 200(66.7) | 175(64.6) | 1.00 (ref) | 148(64.3) | 1.00(ref) | ||
| CT | 87(29.0) | 80(29.5) | 1.011(0.681-1.499) | 0.958 | 67(29.1) | 1.025(0.680-1.546) | 0.905 | |
| TT | 13(4.3) | 16(5.9) | 1.541(0.673-3.527) | 0.306 | 15(6.5) | 1.708(0.741-3.940) | 0.209 | |
| CT+TT vs CC | 1.075(0.740-1.561) | 0.706 | 1.109(0.752-1.634) | 0.602 | ||||
| TT vs CT+CC | 1.536(0.677-3.485) | 0.304 | 1.695(0.742-3.872) | 0.211 | ||||
Abbreviations: SNP: single nucleotide polymorphism; OR: odds ratio; CI: confident interval; * indicates statistical significance (P<0.05). Notes: ORa was adjusted by age, gender and smoking status; Pb-value was adjusted by age, gender and smoking status.