Table 4.
Association between vaginal micro-environment factors change and CIN in different HPV16 infection groups
| Factors | HPV16 negative group | HPV16 positive group | |||||
|---|---|---|---|---|---|---|---|
| Group | Abnormal persons (%) | aOR# (95%CI) | Group | Abnormal persons (%) | aOR# (95%CI) | ||
| H2O2 | NC | 395(72.1) | 1.00 | NC | 57(76.0) | 1.00 | |
| CIN1 | 184(77.0) | 1.34(0.94-1.92) | CIN1 | 56(87.5) | 2.03(1.38-2.98) | ||
| CIN2/3 | 45(86.5) | 2.54(1.12-5.76) | CIN2/3 | 38(92.7) | 4.10(1.60-10.52) | ||
| χ2=6.41,P=0.041; χ2trend =6.10,P=0.014 | χ2=6.42,P=0.040; χ2trend =6.09,P=0.014 | ||||||
| PH | NC | 396(72.3) | 1.00 | NC | 53(70.7) | 1.00 | |
| CIN1 | 179(74.9) | 1.15(0.81-1.64) | CIN1 | 52(81.3) | 1.78(0.79-3.99) | ||
| CIN2/3 | 41(78.8) | 1.43(0.71-2.85) | CIN2/3 | 30(90.2) | 3.69(1.16-11.74) | ||
| χ2=1.43,P=0.490; χ2trend =1.40,P=0.236 | χ2=6.43,P=0.040; χ2trend =6.38,P=0.012 | ||||||
| Vagina cleanness | NC | 213(35.9) | 1.00 | NC | 29(38.7) | 1.00 | |
| CIN1 | 121(50.6) | 1.54(1.13-2.10) | CIN1 | 36(56.3) | 2.05(1.03-4.05) | ||
| CIN2/3 | 31(59.6) | 2.26(1.26-4.04) | CIN2/3 | 29(70.7) | 3.84(1.67-8.83) | ||
| χ2=15.22,P<0.001; χ2trend =15.12,P<0.001 | χ2=11.57,P=0.003; χ2trend =11.47,P=0.00 | ||||||
| β-glucuronidase | NC | 61(10.7) | 1.00 | NC | 8(11.1) | 1.00 | |
| CIN1 | 38(15.9) | 1.44(0.93-2.24) | CIN1 | 17(26.6) | 2.92(1.15-7.38) | ||
| CIN2/3 | 17(32.7) | 3.73(1.97-7.08) | CIN2/3 | 16(39.0) | 4.89(1.83-13.09) | ||
| χ2=19.74,P<0.001; χ2trend =16.51,P<0.001 | χ2=12.93,P=0.002;χ2trend =12.79,P<0.001 | ||||||
| coagulase | NC | 104(19.0) | 1.00 | NC | 20(26.7) | 1.00 | |
| CIN1 | 33(13.8) | 0.65(0.42-1.01) | CIN1 | 10(15.6) | 0.51(0.22-1.19) | ||
| CIN2/3 | 14(26.9) | 1.59(0.82-3.06) | CIN2/3 | 15(36.6) | 1.59(0.70-3.59) | ||
| χ2=6.00,P=0.050; χ2trend =0.01,P=0.910 | χ2=6.05,P=0.048; χ2trend =0.59, P=0.441 | ||||||
| neuraminidase | NC | 125(22.8) | 1.00 | NC | 17(22.7) | 1.00 | |
| CIN1 | 72(30.1) | 1.41(0.98-1.99) | CIN1 | 26(40.6) | 2.34(1.11-4.93) | ||
| CIN2/3 | 24(46.2) | 2.91(1.62-5.22) | CIN2/3 | 26(63.4) | 5.64(2.40-13.25) | ||
| χ2=15.81,P<0.001; χ2trend =14.75,P<0.001 | χ2=18.84,P<0.001;χ2trend =18.64,P<0.001 | ||||||
| leukocyte esterase | NC | 233(42.5) | 1.00 | NC | 29(38.7) | 1.00 | |
| CIN1 | 117(49.0) | 1.33(0.98-1.82) | CIN1 | 33(51.6) | 1.67(0.84-3.32) | ||
| CIN2/3 | 25(48.1) | 1.26(0.71-2.23) | CIN2/3 | 26(63.4) | 3.02(1.33-6.82) | ||
| χ2=3.05,P=0.218; χ2trend =2.47,P=0.116 | χ2=6.78,P=0.034; χ2trend =6.74,P=0.009 | ||||||
#Adjusted by FAC1, FAC2 and FAC3