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. 2020 Jan 1;11(2):272–283. doi: 10.7150/jca.34965

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CD105 decreases drug-sensitivity in JEG-3 cells. Western blot (A) and qRT-PCR (B) confirmed the overexpression or knockdown of CD105 in stable monoclonal CD105-transfected (JEG-3/CD105 OE) or shRNA-transfected (JEG-3/shCD105) cell. (C) Cell viability by a CCK8 assay after treating with different concentrations of MTX or FUDR (*, P<0.05, Student's t-test). (D) IC₅₀ values for MTX and FUDR with respect to JEG-3/CD105 OE and JEG-3/shCD105 cells indicated that overexpression of CD105 significantly decreased the sensitivity, whereas knockdown of CD105 increased drug sensitivity.