Table 4.
Kinetic equation describing the release rates of EM from EM-PRIII solid dispersions prepared using varied feed ratios. Note: Different lower-case letters (such as a, b, c, d, and e) in the same column indicate significant differences in the half-life of EM in different samples (Duncan’s tests, p ≤ 0.05).
| Samples | Kinetic Equation | Equation Type | Correlation Coefficient | Half-life (d) |
|---|---|---|---|---|
| EM technical | Q = 77.596 (1 − e−8.672t) | First-order | 0.99 | 0.12 |
| 1:1 feed ratio EM-PRIII solid dispersions | Q = 63.886 (1 − e−2.284t) | First-order | 0.96 | 0.67 |
| 1:4 feed ratio EM-PRIII solid dispersions | Q = 57.624 (1 − e−0.842t) | First-order | 0.91 | 1.81 |
| 1:10 feed ratio EM-PRIII solid dispersions | Q = 12.969t1/2 + 10.173 | Higuchi | 0.93 | 9.43 |
| 1:50 feed ratio EM-PRIII solid dispersions | Q = 11.695t1/2 + 9.410 | Higuchi | 0.91 | 12.05 |
| 1:100 feed ratio EM-PRIII solid dispersions | Q = 10.661t1/2 + 6.249 | Higuchi | 0.94 | 16.76 |