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. 2019 Nov 30;24(23):4383. doi: 10.3390/molecules24234383

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(A) Intracellular [³H]-paclitaxel in parental cells KB-3-1 and ABCB1-overexpressing cells KB-C2 pretreated with or without tetrandrine (3 μM and 5 μM) and Verapamil (3 μM). (B) Intracellular [³H]-paclitaxel in parental KB-3-1 cells at different time points. (C) Intracellular [³H]-paclitaxel in ABCB1-overexpression KB-C2 cells at different time points. Verapamil, an inhibitor of ABCB1, was used as a positive control. * p < 0.05, versus the controls.