Table 3.
The influence of compound 1d on expression of genes encoding H3, TP53, CDKN1A, BCL-2, and BAX in glioblastoma SNB-19, colorectal carcinoma Caco-2, lung cancer A549, and breast cancer MDA-MB231 cells.
| gene | SNB-19 | Caco-2 | A549 | MDA-MB231 | |
|---|---|---|---|---|---|
| Number of mRNA Copies/μg Total RNA | |||||
| H3 | control | 143+/−41 | 11+/−3 | 23+/-13 | 2+/−1 |
| 1d | 52+/−11 | 45+/−3 | 18+/−5 | 8+/−6 | |
| TP53 | control | 198+/−52 | 65+/−24 | 49+/−17 | 56+/−16 |
| 1d | 128+/−24 | 193+/−16 | 54+/−19 | 46+/−20 | |
| CDKN1A | control | 698+/−34 | 266+/−49 | 1012+/−143 | 710+/−486 |
| 1d | 308+/−51 | 260+/−21 | 969+/−137 | 577+/−308 | |
| BCL-2 | control | 70604+/−7852 | 673718+/−52998 | 22485+/−4794 | 207802+/−15572 |
| 1d | 17497+/−4607 | 723708+/−217134 | 15631+/−2296 | 16495+/−4607 | |
| BAX | control | 995+/−98 | 1062+/−141 | 1181+/−132 | 835+/−63 |
| 1d | 220+/−18 | 969+/−264 | 835+/−231 | 221+/−16 | |
| BCL-2/BAX | control | 71 | 634 | 19 | 249 |
| 1d | 80 | 743 | 18 | 80 | |