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The binding affinity of hit-5 to PLKs-polo-box domain (PBD).
| Compounds | PLK1-PBD [μM] (a) | PLK2-PBD [μM] (a) | PLK3-PBD [μM] (a) | PLK2-PBD/PLK1-PBD | PLK3-PBD/PLK1-PBD |
|---|---|---|---|---|---|
| Hit-5 | 26 ± 5 | >400 | >400 | >15 | >15 |
| Poloxin | 34 ± 7 | 152 ± 11 | 284 ± 17 | 4.5 | 8.4 |
| Thymoquinone | 39 ± 6 | 46 ± 5 | 55 ± 10 | 1.2 | 1.4 |
(a) The results are representative of three independent experiments and are expressed as mean ± SD.
