Table 2.

Experimental data on the uptake efficiency of top 70 CPPs.

Category	Names of CPPs	Experimental Uptake Efficiency	References
Crot (27–39) and its derivatives	CyLoP-1	High, higher than D-Tat peptide, penetratin, and D-R8	[29]
	Crot (27–39)	78% of CyLoP1
	Crot (27–39) derivative 1	63% of CyLoP1
	Crot (27–39) derivative 2	66% of CyLoP1
	Crot (27–39) derivative 3	61% of CyLoP1
	Crot (27–39) derivative 4	59% of CyLoP1
	Crot (27–39) derivative 5	47% of CyLoP1
	Crot (27–39) derivative 6	42% of CyLoP1
	Crot (27–39) derivative 7	75% of CyLoP1
	Crot (27–39) derivative 8	39% of CyLoP1
	Crot (27–39) derivative 9	26% of CyLoP1
	Crot (27–39) derivative 10	79% of CyLoP1
	Crot (27–39) derivative 11	58% of CyLoP1
	Crot (27–39) derivative 12	29% of CyLoP1
	Crot (27–39) derivative 13	83% of CyLoP1
	Crot (27–39) derivative 14	37% of CyLoP1
	Crot (27–39) derivative 15	46% of CyLoP1
Penetratin and its derivatives	Penetratin/pAntp (43–58)	Lower than polyarginines but higher than Tat peptide and transportan	[30]
	pAntp (44–58)	85% of pAntp (43–58)	[31]
	pAntp (45–58)	95% of pAntp (43–58)
	pAntp (46–58)	65% of pAntp (43–58)
	pAntp (47–58)	50% of pAntp (43–58)
	pAntp (48–58)	55% of pAntp (43–58)
	pAntp (49–58)	65% of pAntp (43–58)
	pAntp (50–58)	60% of pAntp (43–58)
	pAntp (51–58)	60% of pAntp (43–58)
	Ala43 substitution mutant of pAntp (43–58)	90% of pAntp (43–58)
	Ala44 substitution mutant of pAntp (43–58)	65% of (pAntp) (43–58)
	Ala45 substitution mutant of pAntp (43–58)	80% of pAntp (43–58)
	Ala46 substitution mutant of pAntp (43–58)	50% of pAntp (43–58)
	Ala47 substitution mutant of pAntp (43–58)	55% of pAntp (43–58)
	Ala48 substitution mutant of pAntp (43–58)	65% of pAntp (43–58)
	Ala49 substitution mutant of pAntp (43–58)	90% of pAntp (43–58)
	Ala50 substitution mutant of pAntp (43–58)	90% of pAntp (43–58)
	Ala51 substitution mutant of pAntp (43–58)	60% of pAntp (43–58)
	Ala52 substitution mutant of pAntp (43–58)	45% of pAntp (43–58)
	Ala54 substitution mutant of pAntp (43–58)	90% of pAntp (43–58)
	Met-Arg	Not available	[32]
	pAntpHD (Pro50)	High Comparable to pAntp (43–58)	[33]
CPP derived from PDX-1 protein	PDX-1-PTD	Not available	[34]
Tumor lineage-homing CPPs	7	Not available	[35]
Peptide 14 and its derivatives	No.14	Higher than Tat peptide	[36]
	No.14–1	Higher than Tat and peptide No. 14
	No.14–2	Higher than Tat peptide
	No.14–7	Higher than Tat and peptide No. 14
	No.14–17	Equal to Peptide No. 14
	No.14–18	Higher than Peptide 14 and equal to peptide 14–1
	No.14–20	Higher than Peptide 14 and equal to peptide 14–1
	No.14–21	Higher than Peptide 14 and equal to peptide 14–1
	No.14–25	Equal to peptide 14
	No.14–30	Higher than peptide 14 and lower than peptide 14–1
	No.14–35	Higher than Peptide 14 and equal to peptide 14–1
Cell-penetrating penta peptides (CPP5s)	Bip1	High About 97% of KLPVM	[37]
	Bip2	About 61% of KLPVM)
	Bip6	About 71% of KLPVM
	Bip15	Not available
	Bip16	About 70% KLPVM
pVEC (CPP derived from murine vascular endothelial cadherin)	pVEC mutant 1	Comparable to pVEC	[38]
	pVEC mutant 2	Higher than pVEC
	pVEC mutant 3	Comparable to pVEC
Tat peptide and its derivatives	Tat (48–60)	High Lower than polyarginine and penetratin but equal to transportan	[30,39]
	Rev (34–50)	High Comparable to Tat (48–60)	[40]
	HIV-1 Rev (34–50)	2.5-6.6 times more than Tat (48–60)	[41]
	Retro - Tat (57–49)	High Compared to Tat (49–57)	[42]
Polyarginines	R6	Lower than R9	[42]
	R9	High
Transportan peptide derivative	Transportan 10 (TP10)	High	[43]
CPPs derived from tumor suppressor protein p14ARF	ARF(1–22)	High Comparable to TP10	[43]
	M918	Higher than Penetratin	[44]
α-helical amphipathic CPPs	II	High	[45]