Table 5.
Solubility prediction of CPG2 and top 70 CPPs conjugated to both N- and C-terminus of CPG2 using the ccsol server.
| Peptide Number | Name of the Conjugate | The Solubility Percentage of CPP-CPG2 N-Terminal Conjugates | The Solubility Percentage of CPG2-CPP C-Terminal Conjugates |
|---|---|---|---|
| 1 | Transportan 10 (TP10)-CPG2 | 86% | 86% |
| 2 | Ala43 substitution mutant of pAntp (43–58)-CPG2 | 79% | 79% |
| 3 | Crot (27–39) derevative 1-CPG2 | 87% | 84% |
| 4 | Crot (27–39) derevative 2-CPG2 | 86% | 83% |
| 5 | Crot (27–39) derevative 3-CPG2 | 86% | 83% |
| 6 | CyLoP-1-CPG2 | 85% | 82% |
| 7 | Crot (27–39) derevative 4-CPG2 | 86% | 82% |
| 8 | Crot (27–39) derevative 5-CPG2 | 85% | 83% |
| 9 | pAntp (49–58)-CPG2 | 82% | 81% |
| 10 | Tat (48–60)-CPG2 | 79% | 82% |
| 11 | pAntp (45–58)-CPG2 | 80% | 79% |
| 12 | Bip15-CPG2 | 84% | 84% |
| 13 | pAntp (47–58)-CPG2 | 81% | 79% |
| 14 | II-CPG2 | 87% | 88% |
| 15 | Crot (27–39) derevative 6-CPG2 | 81% | 85% |
| 16 | Crot (27–39) derevative 7-CPG2 | 84% | 85% |
| 17 | Crot (27–39) derevative 8-CPG2 | 85% | 83% |
| 18 | Crot (27–39) derevative 9-CPG2 | 84% | 84% |
| 19 | pAntp (46–58)-CPG2 | 81% | 80% |
| 20 | 7-CPG2 | 70% | 74% |
| 21 | No.14–2-CPG2 | 70% | 74% |
| 22 | No.14-CPG2 | 71% | 75% |
| 23 | No.14–7-CPG2 | 70% | 74% |
| 24 | Crot (27–39)-CPG2 | 84% | 83% |
| 25 | Crot (27–39) derevative 10-CPG2 | 83% | 83% |
| 26 | Crot (27–39) derevative 11-CPG2 | 83% | 83% |
| 27 | Crot (27–39) derevative 12-CPG2 | 83% | 82% |
| 28 | pVEC mutant 1-CPG2 | 80% | 80% |
| 29 | pVEC mutant 2-CPG2 | 80% | 80% |
| 30 | pVEC mutant 3-CPG2 | 78% | 77% |
| 31 | Crot (27–39) derevative 13-CPG2 | 84% | 82% |
| 32 | ARF(1–22)-CPG2 | 75% | 76% |
| 33 | M918-CPG2 | 75% | 76% |
| 34 | pAntp (51–58)-CPG2 | 84% | 82% |
| 35 | pAntp (44–58)-CPG2 | 79% | 79% |
| 36 | pAntp (50–58)-CPG2 | 83% | 82% |
| 37 | Ala44 substitution mutant of pAntp (43–58)-CPG2 | 79% | 78% |
| 38 | PDX -1-PTD-CPG2 | 79% | 78% |
| 39 | No.14–25-CPG2 | 73% | 75% |
| 40 | No.14–17-CPG2 | 72% | 73% |
| 41 | No.14–18-CPG2 | 71% | 72% |
| 42 | No.14–20-CPG2 | 72% | 73% |
| 43 | No.14–21-CPG2 | 72% | 73% |
| 44 | No.14–35-CPG2 | 70% | 72% |
| 45 | No.14–1-CPG2 | 71% | 72% |
| 46 | 30-CPG2 | 72% | 74% |
| 47 | Ala45 substitution mutant of pAntp (43–58)-CPG2 | 79% | 78% |
| 48 | Ala46 substitution mutant of pAntp (43–58)-CPG2 | 78% | 76% |
| 49 | Ala47 substitution mutant of pAntp (43–58)-CPG2 | 80% | 78% |
| 50 | Ala48 substitution mutant of pAntp (43–58)-CPG2 | 81% | 80% |
| 51 | Ala49 substitution mutant of pAntp (43–58)-CPG2 | 80% | 78% |
| 52 | Ala50 substitution mutant of pAntp (43–58)-CPG2 | 79% | 78% |
| 53 | pAntpHD (Pro50)-CPG2 | 79% | 78% |
| 54 | Ala51 substitution mutant of pAntp (43–58)-CPG2 | 79% | 77% |
| 55 | Ala52 substitution mutant of pAntp (43–58)-CPG2 | 80% | 79% |
| 56 | Met-Arg-CPG2 | 79% | 78% |
| 57 | Ala54 substitution mutant of pAntp (43–58)-CPG2 | 80% | 79% |
| 58 | Penetratin-CPG2 | 79% | 78% |
| 59 | Retro - Tat (57–49)-CPG2 | 82% | 81% |
| 60 | R6-CPG2 | 80% | 82% |
| 61 | R9-CPG2 | 77% | 79% |
| 62 | Crot (27–39) derevative 14-CPG2 | 86% | 81% |
| 63 | Crot (27–39) derevative 15-CPG2 | 85% | 81% |
| 64 | Rev (34–50)-CPG2 | 73% | 74% |
| 65 | HIV-1 Rev (34–50)-CPG2 | 74% | 73% |
| 66 | Bip6-CPG2 | 84% | 85% |
| 67 | Bip1-CPG2 | 84% | 85% |
| 68 | Bip2-CPG2 | 84% | 85% |
| 69 | Bip16-CPG2 | 83% | 85% |
| 70 | pAntp (48–58)-CPG2 | 82% | 79% |
| CPG2 | 83% | 83% |