Table 6.

Thermodynamic quantities of CPG2 and 70 top CPPs conjugated to CPG2 using the SCOOP server.

Peptide Number	Name of the Conjugate	N-Terminal Conjugates		C-Terminal Conjugates
		Tm (degree~C)	ΔGr (kcal.mol−1)	Tm (degree~C)	ΔGr (kcal.mol−1)
1	Transportan 10 (TP10)-CPG2	64.1	−12.3	60.9	−15.9
2	Ala43 substitution mutant of pAntp (43-58)-CPG2	59.1	−13.1	60.7	−11.6
3	Crot (27−39) derivative 1-CPG2	61.2	−13.3	61.7	−13.1
4	Crot (27−39) derivative 2-CPG2	60.7	−14.2	61.7	−13.1
5	Crot (27−39) derivative 3-CPG2	61.3	−14.1	59.0	−14.0
6	CyLoP-1-CPG2	62.0	−13.2	61.5	−13.6
7	Crot (27−39) derivative 4-CPG2	63.1	−14.0	65.8	−13.8
8	Crot (27−39) derivative 5-CPG2	62.4	−13.1	60.2	−15.0
9	pAntp (49−58)-CPG2	60.5	−16.0	59.3	−16.6
10	Tat (48−60)-CPG2	60.1	−13.4	68.0	−13.6
11	pAntp (45−58)-CPG2	59.1	−16.1	60.0	−14.1
12	Bip15-CPG2	60.7	−12.7	63.1	−14.4
13	pAntp (47−58)-CPG2	59.7	−15.4	62.2	−13.2
14	II-CPG2	59.7	−15.4	62.5	−14.8
15	Crot (27−39) derivative 6-CPG2	62.8	−13.3	62.3	−12.9
16	Crot (27−39) derivative 7-CPG2	61.7	−15.9	64.1	−15.2
17	Crot (27−39) derivative 8-CPG2	61.1	−14.8	60.3	−15.9
18	Crot (27−39) derivative 9-CPG2	59.1	−13.2	61.7	−13.3
19	pAntp (46−58)-CPG2	63.0	−12.7	61.2	−14.6
20	7-CPG2	62.7	−12.8	60.2	−12.8
21	No.14−2-CPG2	61.9	−15.1	59.6	−13.6
22	No.14-CPG2	64.7	−15.4	59.8	−14.8
23	No.14−7-CPG2	63.6	−14.4	63.0	−12.6
24	Crot (27−39)-CPG2	61.4	−15.0	61.0	−14.9
25	Crot (27−39) derivative 10-CPG2	60.6	−14.7	57.3	−13.0
26	Crot (27−39) derivative 11-CPG2	61.0	−15.1	58.9	−15.4
27	Crot (27−39) derivative 12-CPG2	60.5	−13.6	59.5	−13.9
28	pVEC mutant 1-CPG2	63.8	−14.0	64.2	−12.0
29	pVEC mutant 2-CPG2	60.2	−16.8	57.9	−15.8
30	pVEC mutant 3-CPG2	63.8	−11.2	62.1	−13.7
31	Crot (27−39) derivative 13-CPG2	64.2	−14.3	58.5	−13.3
32	ARF(1−22)-CPG2	61.0	−16.3	65.4	−12.4
33	M918-CPG2	65.5	−14.8	63.3	−12.6
34	pAntp (51−58)-CPG2	56.9	−15.8	61.6	−15.3
35	pAntp (44−58)-CPG2	58.1	−13.6	59.5	−16.8
36	pAntp (50−58)-CPG2	62.7	−15.6	61.0	−13.6
37	Ala44 substitution mutant of pAntp (43−58)-CPG2	60.7	−13.8	58.4	−15.6
38	PDX -1-PTD-CPG2	57.6	−13.9	58.5	−14.2
39	No.14−25-CPG2	62.3	−11.5	58.5	−15.3
40	No.14−17-CPG2	60.3	−14.6	58.7	−14.9
41	No.14−18-CPG2	60.6	−13.3	61.6	−13.9
42	No.14−20-CPG2	62.3	−14.1	56.6	−15.2
43	No.14−21-CPG2	63.8	−14.8	60.8	−14.2
44	No.14−35-CPG2	62.5	−15.9	59.9	−15.4
45	No.14−1-CPG2	61.7	−15.5	60.7	−13.4
46	30-CPG2	62.8	−13.8	58.3	−15.0
47	Ala45 substitution mutant of pAntp (43−58)-CPG2	60.2	−14.0	59.7	−16.3
48	Ala46 substitution mutant of pAntp (43−58)-CPG2	63.2	−12.9	60.4	−14.6
49	Ala47 substitution mutant of pAntp (43−58)-CPG2	60.6	−13.6	61.3	−13.0
50	Ala48 substitution mutant of pAntp (43−58)-CPG2	62.2	−14.0	57.1	−16.1
51	Ala49 substitution mutant of pAntp (43−58)-CPG2	61.1	−14.6	60.7	−14.7
52	Ala50 substitution mutant of pAntp (43−58)-CPG2	60.8	−13.3	59.5	−15.3
53	pAntpHD (Pro50)-CPG2	62.7	−12.7	60.7	−13.4
54	Ala51 substitution mutant of pAntp (43−58)-CPG	60.3	−14.9	56.6	−13.4
55	Ala52 substitution mutant of pAntp (43−58)-CPG2	63.9	−11.9	61.1	−13.4
56	Met-Arg-CPG2	64.2	−14.3	59.6	−14.3
57	Ala54 substitution mutant of pAntp (43−58)-CPG2	60.4	−14.7	59.5	−14.9
58	Penetratin-CPG2	60.4	−15.1	60.0	−12.5
59	Retro - Tat (57−49)-CPG2	61.0	−14.0	60.4	−14.7
60	R6-CPG2	58.7	−14.3	62.0	−14.4
61	R9-CPG2	62.7	−13.8	57.7	−15.5
62	Crot (27−39) derivative 14-CPG2	63.5	−13.2	62.6	−13.0
63	Crot (27−39) derivative 15-CPG2	60.3	−13.6	63.0	−15.1
64	Rev (34−50)-CPG2	59.1	−16.4	58.5	−16.0
65	HIV-1 Rev (34−50)-CPG2	62.0	−13.3	59.9	−15.2
66	Bip6-CPG2	62.6	−15.0	62.6	−13.9
67	Bip1-CPG2	56.7	−14.9	63.4	−11.2
68	Bip2-CPG2	60.8	−13.7	60.5	−13.0
69	Bip16-CPG2	61.8	−14.6	61.4	−14.3
70	pAntp (48−58)-CPG2	56.5	−15.6	59.5	−13.5
	CPG2	61.7	−15.1	61.7	−15.1