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Synthetic strategy followed for the synthesis of compounds 2–6. (a) phenylboronic acid, K2CO3, Pd(OAc)2, TBAB, DMF, 150 °C (microwave (MW) irradiation), 15 min; (b) DMTCl, DABCO, DMF, 70 °C, 3 h; (c) diphenyl ether, argon, 240 °C (MW irradiation), 20 min; (d) malonic acid, anhydrous pyridine, piperidine, 70 °C, 4–5 h; (e) 1. DMF, DIPEA, PyBOP, CH2Cl2, 0 °C, 30 min; 2. benzylamine or 2-phenylethylamine, rt, overnight; (f) MeOH, aqueous solution of NaOH 2 M, reflux, 1.5–16 h.
