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. 2019 Nov 26;24(23):4319. doi: 10.3390/molecules24234319

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Scheme 1 — Synthesis of compounds 1a–9i. (a) 1. nBuLi, THF, −78 °C; 2. 3,4,5-trimethoxybenzoic acid, NaH, 0 °C—rt; (b) 1. nBuLi, THF, −78 °C; 2. ArCHO, THF; 3. PDC, HSO₄ Bu₄N; (c) NH₂OH·HCl, pyridine, MeOH, reflux; (d) Ph₃PMeI, nBuLi, THF, −40 °C; (e) H₂, Pd/C, EtOH, rt; (f) MeI, acetone, reflux; (g) nBuLi, THF, −78 °C.