Table 2.

PMS patients with neuropsychiatric decompensation and atrophy on brain imaging

Case	Age at imaging	Imaging technique	Findings	Proposed diagnosis on review
2	27 y	CT	Diffuse mild cortical atrophy and hydrocephalus ex vacuo	Bipolar disorder with catatonia
10	12 y	MRI	Diffuse cerebral and cerebellar atrophy	Metachromatic leukodystrophy
11	52 y	CT	Cerebral atrophy, with multiple intracranial meningiomas	Bipolar disorder with catatonia, neurofibromatosis type 2
22	45 y	MRI	Normal, except for mild enlargement of the cisterna magna and central atrophy	Progressive neurological disorder
26	19, 25, and 41 y	CT	Corticosubcortical atrophy	Bipolar disorder
28	43 y	CT	Mild corticosubcortical atrophy	Bipolar disorder
31	70 y	MRI	Cortical atrophy, particularly in the frontal region, and subtle periventricular white matter changes	Bipolar disorder with catatonia
43	NA (between 20 and 46 y)	NA	Cerebral and cerebellar atrophy	Unspecified psychotic disorder with catatonia
45	42 y	MRI	Discrete loss of cerebral tissue predominantly in the left hemisphere with enlarged sulci	Bipolar disorder
56	NA (between 23 and 30 y)	MRI	Incipient cortical atrophy	Bipolar disorder with catatonia

CT computed tomography, MRI magnetic resonance imaging, NA not available, y years