Table 3.
Prognostic factors for overall survival and progression-free survival in all patients with dedifferentiated chondrosarcoma by multivariate analysis.
| Variable | Overall survival | Progression-free survival | ||||
|---|---|---|---|---|---|---|
| HR | 95.0% CI | P | HR | 95.0% CI | P | |
| Pathological fracture | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 2.77 | 1.53–5.03 | 0.001 | 2.97 | 1.66–5.30 | <0.001 |
|
| ||||||
| Tumor size | ||||||
| ≤8 cm | 1.00 | 0.001 | NS | |||
| >8 cm | 3.43 | 1.73–6.79 | <0.001 | |||
| Discontinuous | 3.73 | 0.96–14.56 | 0.058 | |||
|
| ||||||
| Lymph node involvement | ||||||
| No | 1.00 | NS | ||||
| Yes | 5.27 | 1.26–22.08 | 0.023 | |||
|
| ||||||
| Distant metastasis | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 5.31 | 2.63–10.74 | <0.001 | 5.21 | 2.73–9.95 | <0.001 |
|
| ||||||
| Extraosseous extension | ||||||
| No | 1.00 | NS | ||||
| Yes | 5.24 | 1.11–24.70 | 0.036 | |||
|
| ||||||
| UPS component | ||||||
| No | 1.00 | NS | ||||
| Yes | 2.44 | 1.31–4.57 | 0.005 | |||
|
| ||||||
| Surgical resection | ||||||
| No | 1.00 | NS | ||||
| Yes | 0.21 | 0.08–0.55 | 0.002 | |||
|
| ||||||
| Chemotherapy | ||||||
| No | 1.00 | 1.00 | ||||
| Yes | 0.23 | 0.12–0.44 | <0.001 | 0.43 | 0.24–0.77 | 0.005 |
CI, confidence interval; HR, hazard ratio; NS, not significant; UPS, undifferentiated pleomorphic sarcoma.