Table 4.
Significant prognostic factors for local relapse-free survival and metastasis-free survival in patients with nonmetastatic dedifferentiated chondrosarcoma by univariate and multivariate analyses.
| Variable | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| Median (months) | 95% CI | P | HR | 95% CI | P | |
| Local relapse-free survival | 61.7 | |||||
| Pathological fracture | 0.008 | NS | ||||
| No | Not reached | |||||
| Yes | 11.0 | 0–25.5 | ||||
| Lymphovascular invasion | 0.024 | NS | ||||
| No | Not reached | |||||
| Yes | 11.0 | 0–22.3 | ||||
| NA | 61.7 | 0–142.4 | ||||
| Surgical margin | 0.002 | |||||
| R0 | Not reached | 1.00 | 0.004 | |||
| R1/R2 | 10.2 | 1.2–19.1 | 7.51 | 2.51–22.46 | <0.001 | |
| No surgery | 61.7 | 1.98 | 0.25–15.99 | 0.520 | ||
|
| ||||||
| Metastasis-free survival | 18.1 | 6.2–30.0 | ||||
| Pathological fracture | 0.017 | NS | ||||
| No | 31.6 | 0–82.3 | ||||
| Yes | 6.4 | 3.1–9.7 | ||||
| Size of dedifferentiated component | 0.017 | 0.044 | ||||
| Microscopic | Not reached | 1.00 | ||||
| Macroscopic | 9.0 | 6.4–11.6 | 7.78 | 1.06–57.17 | ||
CI, confidence interval; HR, hazard ratio; NS, not significant.