Table 5.
Multiple logistic regression analysis predicts an association of intestinal alkaline phosphatase (IAP) deficiency with ischemic heart disease (IHD).
| Explanatory variables | Logistic coefficient per unit change | Odds ratio (95% CI) |
|---|---|---|
| IAP (U/g stool) | -0.00730∗∗ | 0.993 (0.987-0.998) |
| Sex (ref = male) | -0.3759∗∗ | 0.471 (0.288-0.771) |
| Age (yr.) | 0.0284∗ | 1.029 (1.001-1.057) |
| Body mass index (BMI, kg/m2) | -0.00894 | 0.991 (0.936-1.050) |
| Creatinine (mmol/l) | 0.0364∗∗∗ | 1.037 (1.025-1.049) |
| Total cholesterol (mg/dl) | 0.00114 | 1.001 (0.983-1.020) |
| HDL-cholesterol (mg/dl) | -0.0362 | 0.964 (0.930-1.000) |
| LDL-cholesterol (mg/dl) | 0.0127 | 1.013 (0.994-1.032) |
| Triglycerides (mg/dl) | 0.000809 | 1.001 (0.997-1.005) |
| ALT (U/l) | 0.0110∗∗ | 1.011 (1.003-1.019) |
| Systolic blood pressure (mmHg) | -0.0746∗∗∗ | 0.928 (0.911-0.945) |
| Diastolic blood pressure (mmHg) | 0.0660∗∗∗ | 1.068 (1.039-1.098) |
| FPG (mmol/l) | 0.4717∗∗∗ | 1.603 (1.339-1.918) |
| Area under the curve (AUC) = 0.89 | ||
Multiple logistic regression analysis reveals that the IAP level is negatively associated with log-odds of IHD. For one unit (U/g stool) increase in the IAP level, the odds of developing IHD is decreased by 1% controlling for other risk factors, which indicates that high IAP level is probably protective against IHD. Statistics: Proc Logist procedure (SAS) was used for multiple logistic regression analysis determining association between IHD and independent risk factors (explanatory variables) including IAP. p < 0.05 is considered significant. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001.