Table 5.
Body weight gain in the 90-day study.
| Group (mg/kg bw/day) | Body weight gain (g) between days | |||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Treatment period | Recovery Period | |||||||||||||||||||||||
| 0–4 | 4–7 | 7–11 | 11–14 | 14–18 | 18–21 | 21–25 | 25–28 | 28–35 | 35–42 | 42–49 | 49–56 | 56–63 | 63–70 | 70–77 | 77–84 | 84–89 | 0–89 | 90–97 | 97–104 | 104–111 | 111–117 | 90–117 | ||
| Male | ||||||||||||||||||||||||
| 0 (Control) | Mean | 27.3 | 17.7 | 24.1 | 14.5 | 19.1 | 10.1 | 15.2 | 10.1 | 20.6 | 15.4 | 14.7 | 14.1 | 9.6 | 6.9 | 10.9 | 7.3 | 2.3 | 239.9 | 9.8 | 4.0 | 3.4 | 10.2 | 27.4 |
| (n = 15†) | SD | 2.9 | 3.5 | 3.0 | 2.6 | 3.3 | 2.1 | 3.2 | 3.1 | 3.8 | 3.4 | 5.3 | 3.9 | 2.9 | 2.9 | 3.7 | 4.0 | 3.8 | 24.9 | 3.3 | 1.6 | 3.9 | 1.1 | 6.3 |
| 75 | Mean | 25.0 | 15.5 | 18.9 | 13.1 | 18.9 | 6.3 | 17.0 | 8.3 | 22.7 | 16.0 | 15.3 | 15.3 | 11.7 | 8.1 | 11.0 | 9.4 | 1.5 | 234.0 | |||||
| (n = 10) | SD | 3.7 | 4.0 | 5.2 | 2.0 | 5.6 | 3.4 | 3.6 | 2.7 | 4.9 | 5.3 | 5.4 | 4.1 | 6.2 | 4.3 | 4.0 | 3.3 | 3.1 | 36.3 | |||||
| SS | ∗∗ | ∗∗ | ||||||||||||||||||||||
| 112 | Mean | 23.9 | 15.8 | 22.4 | 12.6 | 21.0 | 9.7 | 16.8 | 8.7 | 21.8 | 16.3 | 14.1 | 14.6 | 9.2 | 6.8 | 10.9 | 9.7 | −0.3 | 234.0 | |||||
| (n = 10) | SD | 4.7 | 3.0 | 3.7 | 2.6 | 3.9 | 2.3 | 3.9 | 2.0 | 3.5 | 7.0 | 3.4 | 7.1 | 3.7 | 4.6 | 4.7 | 4.6 | 4.4 | 20.4 | |||||
| SS | ∗ | |||||||||||||||||||||||
| 150 | Mean | 20.7 | 15.5 | 18.3 | 14.4 | 16.8 | 7.1 | 16.6 | 3.8 | 21.2 | 13.7 | 11.5 | 12.5 | 10.0 | 4.6 | 10.3 | 6.7 | 3.2 | 206.9 | |||||
| (n = 10) | SD | 5.2 | 3.9 | 2.9 | 1.6 | 4.7 | 4.5 | 2.9 | 3.5 | 4.5 | 3.7 | 5.1 | 2.6 | 3.7 | 3.3 | 5.0 | 4.7 | 3.3 | 24.9 | |||||
| SS | ∗∗ | ∗∗ | ∗ | ∗∗ | ∗∗ | |||||||||||||||||||
| 187 | Mean | 19.5 | 14.0 | 15.5 | 10.2 | 16.4 | 7.1 | 17.0 | 5.5 | 20.2 | 13.3 | 6.5 | 13.3 | 9.3 | 6.0 | 7.1 | 6.1 | 3.8 | 190.8 | |||||
| (n = 10) | SD | 4.4 | 3.5 | 4.3 | 4.1 | 4.8 | 5.5 | 3.5 | 3.7 | 8.1 | 3.1 | 2.9 | 4.9 | 4.2 | 5.3 | 3.2 | 3.5 | 4.5 | 27.9 | |||||
| SS | ∗∗ | ∗ | ∗∗ | ∗∗ | ∗∗ | ∗∗ | ∗∗ | |||||||||||||||||
| 225 | Mean | 17.3 | 11.9 | 13.0 | 8.7 | 11.9 | 6.2 | 13.9 | 4.7 | 16.3 | 7.9 | 7.8 | 9.7 | 5.2 | 5.7 | 8.0 | 6.8 | 1.7 | 156.5 | 15.2 | 23.4 | 15.4 | 9.6 | 63.6 |
| (n = 15†) | SD | 2.8 | 4.0 | 3.8 | 3.5 | 3.5 | 3.3 | 2.9 | 2.7 | 5.3 | 3.3 | 4.1 | 4.4 | 4.8 | 4.3 | 4.5 | 3.9 | 3.6 | 25.0 | 7.7 | 7.5 | 6.4 | 3.9 | 23.1 |
| SS | ∗∗ | ∗∗ | ∗∗ | ∗∗ | ∗∗ | ∗∗ | ∗∗ | ∗ | ∗∗ | ∗∗ | ∗ | ∗ | ∗∗ | ∗∗ | ∗∗ | ∗ | ||||||||
| Test for significance | DN | DN | DN | DN | DN | U | NS | DN | DN | U | DN | DN | DN | NS | NS | NS | NS | DN | NS | T | T | NS | T | |
| Female | ||||||||||||||||||||||||
| 0 (Control) | Mean | 13.2 | 6.6 | 12.4 | 5.7 | 10.1 | 5.5 | 6.3 | 4.9 | 7.5 | 8.4 | 5.6 | 3.1 | 6.5 | 3.4 | 0.9 | 4.7 | 3.6 | 108.3 | −0.6 | 3.2 | −1.0 | 1.8 | 3.4 |
| (n = 15†) | SD | 2.4 | 2.6 | 2.9 | 4.5 | 2.3 | 4.9 | 2.3 | 2.9 | 2.7 | 4.7 | 3.9 | 3.1 | 2.5 | 4.2 | 3.0 | 3.8 | 3.7 | 14.6 | 4.5 | 4.7 | 2.7 | 3.3 | 6.5 |
| 75 | Mean | 13.1 | 6.5 | 12.3 | 5.8 | 9.9 | 3.3 | 6.6 | 3.5 | 12.0 | 7.0 | 6.4 | 5.7 | 7.7 | 3.4 | 1.7 | 3.2 | 4.4 | 112.5 | |||||
| (n = 10) | SD | 4.1 | 3.7 | 2.8 | 3.2 | 2.5 | 2.7 | 3.3 | 3.0 | 4.0 | 3.8 | 4.4 | 5.1 | 1.7 | 3.9 | 3.9 | 4.7 | 3.6 | 8.2 | |||||
| SS | ∗∗ | |||||||||||||||||||||||
| 112 | Mean | 13.1 | 8.1 | 11.1 | 5.8 | 9.4 | 3.7 | 6.7 | 3.6 | 10.7 | 8.0 | 7.3 | 6.0 | 5.6 | 4.8 | −0.1 | 3.0 | 6.0 | 112.8 | |||||
| (n = 10) | SD | 3.8 | 3.0 | 3.6 | 2.0 | 2.7 | 3.7 | 2.5 | 3.6 | 4.1 | 3.0 | 4.9 | 3.7 | 3.9 | 3.9 | 5.1 | 2.1 | 4.1 | 12.6 | |||||
| SS | ∗ | ∗ | ||||||||||||||||||||||
| 150 | Mean | 11.6 | 9.2 | 11.6 | 6.3 | 9.6 | 2.9 | 8.1 | 3.0 | 12.5 | 7.1 | 6.7 | 7.9 | 3.7 | 3.4 | 4.3 | 4.4 | 1.8 | 114.1 | |||||
| (n = 10) | SD | 2.2 | 2.9 | 2.0 | 2.4 | 1.8 | 4.0 | 2.2 | 3.6 | 3.8 | 3.5 | 2.8 | 2.1 | 2.2 | 3.0 | 3.7 | 3.6 | 2.6 | 14.8 | |||||
| SS | ∗∗ | ∗∗ | ∗ | |||||||||||||||||||||
| 187 | Mean | 13.0 | 8.4 | 12.8 | 6.9 | 9.8 | 2.5 | 9.6 | 2.3 | 10.3 | 8.3 | 5.2 | 6.5 | 6.2 | 3.6 | 5.3 | 4.1 | 3.7 | 118.5 | |||||
| (n = 10) | SD | 2.1 | 1.8 | 5.3 | 2.8 | 3.2 | 3.2 | 2.4 | 2.3 | 2.5 | 1.6 | 3.3 | 2.4 | 2.3 | 4.2 | 4.0 | 2.8 | 2.6 | 17.4 | |||||
| SS | ∗ | ∗ | ∗ | ∗ | ||||||||||||||||||||
| 225 | Mean | 10.1 | 8.3 | 11.0 | 4.4 | 8.9 | 4.0 | 8.7 | 3.0 | 10.9 | 5.9 | 4.8 | 8.1 | 4.4 | 4.3 | 2.5 | 3.1 | 2.1 | 104.6 | −5.4 | 4.6 | 0.4 | 0.6 | 0.2 |
| (n = 15†) | SD | 2.1 | 2.7 | 3.5 | 3.6 | 3.3 | 2.1 | 3.7 | 4.6 | 6.3 | 4.2 | 3.0 | 2.7 | 2.3 | 2.7 | 4.2 | 3.2 | 4.3 | 14.6 | 2.6 | 5.0 | 3.2 | 2.1 | 5.8 |
| SS | ∗∗ | ∗ | ∗∗ | ∗ | ||||||||||||||||||||
| Test for significance | DN | NS | NS | NS | NS | NS | DN | NS | U | NS | NS | DN | DN | NS | DN | NS | NS | NS | NS | NS | NS | NS | NS | |
Abbreviations: DN, Duncan's multiple range test; NS, not significant; SD, standard deviation; SS, statistically significant compared to control; TT-test versus control; U, Mann-Whitney U-test versus control.
†Recovery period (n = 5). ∗p < 0.05, ∗∗p < 0.01.