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. 2019 Dec 13;2019:3643715. doi: 10.1155/2019/3643715

Figure 4.

Figure 4

Alpha-lipoic acid inhibits invasion of AGS cells by suppressing MUC4 expression. (a) AGS cells were incubated with either 2 mM ALA or 200 ng/mL MUC4 antibody in a BioCoat™ Matrigel apparatus with 8 μM pore membrane for 24 h. (b) AGS cells were incubated with 20 ng/mL TNF-α in the presence or absence of 2 mM ALA or 200 ng/mL MUC4 antibody in a BioCoat™ Matrigel apparatus for 24 h. (c) AGS cells were incubated with 20 ng/mL TNF-α in the presence of 0-2.5 mM alpha-lipoic acid or 200 ng/mL MUC4 antibody. After incubation, the cells that invaded the lower surface of the chambers were counted using a phase contrast light microscope after staining with a Diff-Quick Stain kit. Data represent the mean ± SD from 3 independent experiments. #p < 0.05 versus control; ∗p < 0.05 versus TNF-α only.