Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Dec 17;7:411. doi: 10.3389/fbioe.2019.00411

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Lin, Li, Li, Li, Del Duke, Shen, Hao, O'Donnell, Bunnell, Goodman, Alexander, Tuan and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Creation of OA model in iMPCs-derived tissue chip. (A) Schematic of the process. After 28 days of differentiation and the formation of OC or CH, 1 ng/ml IL-1β was introduced into the top flow and perfused only onto the cartilage component. (B) Expression levels of anabolic factors (ACAN, COL2), proinflammatory cytokines (IL-1β, IL-6), and catabolic factors in OC or CH, with or without the treatment of IL-1β. All data are normalized to RPL13A. N = 4 per group. *p < 0.05; **p < 0.01; ***p< 0.001; ****p< 0.0001. (C) Alcian Blue staining of cartilage from OC or CH samples, with or without the treatment of IL-1β. Bar = 200 μm.