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. 2019 Dec 16;13:553. doi: 10.3389/fncel.2019.00553

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Copyright © 2019 Ye, Jin, Zhang, Zeng, Ye, Wang, Zhong, Xiong and Gu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Meisoindigo treatment inhibits NLRP3 inflammasome activation through down-regulation of TLR4 pathways after OGD/R in HT-22. (A) Representative Western blot membranes for TLR4, NF-κB p65, phosphorylated NF-κB p65, NLRP3, ASC, CL-caspase-1, and IL-1β. Quantitative analysis of TLR4 (B), NF-κB p65 (C), phosphorylated NF-κB p65 (D), NLRP3 (E), ASC (F), CL-caspase-1 (G), and IL-1β (H) proteins expression levels. Mean ± SD; n = 3/group. ^aP < 0.05 vs. sham; ^bP < 0.05 vs. vehicle + OGD/R; ^cP < 0.05 vs. LPS + OGD/R.