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. 2019 Dec 16;13:553. doi: 10.3389/fncel.2019.00553

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Copyright © 2019 Ye, Jin, Zhang, Zeng, Ye, Wang, Zhong, Xiong and Gu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Meisoindigo suppresses the activation of the TLR-4/NF-κB signaling pathway in dose dependent manners. (A) Representative western blot showing that Mei treatment reduces the expression of TLR-4/NF-κB signaling pathway-related proteins in dose dependent manners. Quantitative analysis of the protein levels of TLR4 (B), NF-κB p65 (C), phosphorylated NF-κB p65 (D), and IL-1β (E). Mean ± SD; n = 8/group. ^aP < 0.05 vs. sham; ^bP < 0.05 vs. vehicle; ^cP < 0.05 vs. TAK-242; ^dP < 0.01 vs. 2 mg/kg Mei; ^eP < 0.01 vs. 4 mg/kg Mei.