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. 2019 Nov 16;8(12):931–939. doi: 10.1002/psp4.12472

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© 2019 The Authors. CPT: Pharmacometrics & Systems Pharmacology published by Wiley Periodicals, Inc. on behalf of the American Society for Clinical Pharmacology and Therapeutics.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Schematic representation of a physiologically‐based pharmacokinetics model for paclitaxel in the mice. CL_int, intrinsic clearance; IV, intravenous; Psr, permeability surface area conduct; Q_B, brain blood flow rate; Q_F, fat blood flow rate; Q_G, gut blood flow rate; Q_H, heart blood flow rate; Q_K, kidney blood flow rate; Q_L, liver blood flow rate; Q_Lu, lung blood flow rate; Q_M, muscle blood flow rate; Q_S, spleen blood flow rate.