Table 1.

Paclitaxel pharmacokinetic parameter estimation and precision (CV%) in mouse plasma and tissue using the proposed PBPK model

Organ	Parameter	NCA estimated	PBPK estimated	CV%	2.5% CI	97.5% CI	Difference, %
Spleen	K s	0.73	0.83	14.06	0.59	1.06	10.97
Kidney	K k	1.03	1	13.41	0.73	1.28	2.34
Heart	K h	0.49	0.54	13.95	0.38	0.69	7.78
Lung	K lu	0.78	0.77	13.67	0.56	0.99	1.26
Liver	K l	2.74	2.8	13.66	2.02	3.58	1.99
	Clint,H (mL/hour)	89.26	79.72	11.7	60.69	98.74	11.97
Gut	K g	1.32	1.61	14.23	1.14	2.08	18.09
Muscle	K m	0.38	0.37	13.87	0.27	0.48	1.27
Fat	K f	0.61	0.58	13.95	0.42	0.75	5.6
Brain	K br	0.03	0.03	13.65	0.03	0.04	8.36
Remainder	K r		0.52	35.05	0.15	0.9
	PSr (mL/hour)		43	14.85	29.98	56.02
	K ISF		2.63	29.47	1.05	4.21

CI, confidence interval; CV%, coefficient of variation; NCA, noncompartmental pharmacokinetic analysis; PBPK, physiologically‐based pharmacokinetic; K_s, spleen partition coefficient; K_k, kidney partition coefficient; K_h, heart partition coefficient; K_lu, lung partition coefficient; K_l, liver partition coefficient; K_g, gut partition coefficient; K_m, muscle partition coefficient; K_f, fat partition coefficient; H_br, brain partition coefficient; K_r, reminder partition coefficient; Cl_int,H, intrinsic clearance; PS_r, permeability surface area conduct; K_ISF, interstitial fluid partition coefficient.