TABLE 1.

Representative regulators of antibiotic biosynthesis with antibiotics and/or their biosynthetic intermediates as regulatory ligands.

Regulators	Ligands	Description	References
JadR1	JdB, JdA, DHU, DHR	TetR family, activator of jadomycin biosynthesis; repressor of chloramphenicol biosynthesis	Wang et al., 2009
RedZ	RED	TetR family, activator of RED biosynthesis	Wang et al., 2009
JadR∗	DHU, DHR, JdA, JdB	TetR family, repressor of jadomycin biosynthesis	Zhang et al., 2013
ChlF1	CHL, DM-CHL, deschloro-CHL	TetR family, repressor of chlorothricin biosynthesis	Li et al., 2016
CalR3	calcimycin, cezomycin	TetR family, repressor of calcimycin biosynthesis	Gou et al., 2017
NosP	NOS, NOS-AC	SARP family, activator of nosiheptide production	Li et al., 2018
RifQ	rifamycin B	TetR family, repressor of rifamycin biosynthesis	Lei et al., 2018
PhlH	2,4-DAPG, MAPG	TetR family, repressor of 2,4-diacetylphloroglucinol biosynthesis	Yan et al., 2017
ScbR2	ACT, RED	TetR family, repressor of coelimycin biosynthesis	Xu et al., 2010
JadR2	JdB, Cm	TetR family, repressor of jadomycin biosynthesis; activator of chloramphenicol	Xu et al., 2010

JdB, jadomycin B; JdA, jadomycin A; DHU, 2,3-dehydro-UWM6; DHR, dehydrorabelomycin; RED, undecylprodigiosin; CHL, chlorothricin; DM-CHL, demethylsalicycloyl chlorothricin; deschloro-CHL, deschloro-chlorothricin; NOS, nosiheptide; NOS-AC, the intermediate of NOS; 2,4-DAPG, 2,4-diacetylphloroglucinol; MAPG, monoacetylphloroglucinol; ACT, actinorhodin; Cm, chloramphenicol.