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. 2019 Dec 19;10:1299. doi: 10.3389/fneur.2019.01299

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Copyright © 2019 Zhang, Jiang, Liu, Shen, Jung, Liu and Yan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The PPI networks construction and analysis for SEH against CIS. (A) PPI networks of SEH-related targets and CIS targets. (B) The interactive PPI network of SEH and CIS targets gained from (A). (C) The PPI network of key targets of SEH acting on CIS obtained from (B). Pink square node in (A,B) represent direct targets of SEH and CIS. Blue nodes represent indirect targets of SEH and CIS. Pink circular nodes in (C) represent key targets of SEH acting on CIS, while its size is proportional to the significance. Edges represent interactions among SEH and CIS targets. PPI, protein-protein interaction; SEH, senkyunolide-H; CIS, cerebral ischemic stroke.